P57 SUPPRESSES THE PLURIPOTENCY AND PROLIFERATION OF MOUSE EMBRYONIC STEM CELLS BY POSITIVELY REGULATING P53 ACTIVATION

p57 Suppresses the Pluripotency and Proliferation of Mouse Embryonic Stem Cells by Positively Regulating p53 Activation

Embryonic stem cells (ESCs) are pluripotent stem cells that have indefinite self-renewal capacities under appropriate culture conditions in vitro.The pluripotency maintenance and proliferation of these cells are delicately governed by the concert effect of a complex transcriptional regulatory network.Herein, we discovered that p57Kip2 (p57), a cycl

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In vivo approaches reveal a key role for DCs in CD4+ T cell activation and parasite clearance during the acute phase of experimental blood-stage malaria.

Dendritic cells (DCs) are phagocytes that are highly specialized for antigen presentation.Heterogeneous populations of macrophages and DCs form a phagocyte network inside the red pulp (RP) of Sailing Boots the spleen, which is a major site for the control of blood-borne infections such as malaria.However, the dynamics of splenic DCs during Plasmodi

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Vitamin D and Gestational Diabetes Mellitus: Is There a Link?

Gestational diabetes mellitus (GDM) is a very common condition among pregnant women worldwide with important metabolic implications on the mother and the offspring.Vitamin D status has been suggested to potentially play a role in GDM risk with no documented consequences for the offspring.The purpose of this article was to review currently available

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